Stone man syndrome

Also called Fibrodysplasia ossificans progressiva is a rare autosomal dominant disorder caused by the mutation of the gene ACVR1. It is the only known medical condition where one organ system changes into another. (A connective tissue disorder)Usual onset: Before the age of 10 with maximum life expectancy of 40 years. (Painful condition indeed with no treatment or cure)Mutations mainly affects body’s repair mechanism causing fibrous tissue including muscles, tendons and ligaments to be ossified either spontaneously or damaged as a result of trauma. Sometimes joints fuse themselves to form new bone. Bone growth generally progresses from the top of the body downwards just like ossification found in foetus.Signs: Malformed big toes, missing joints etc.
Since the disorder is rare, it is often misdiagnosed as cancer/ fibrosis.

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