The drug which can treat the patients infected with corona virus.

Remdesivir is a novel antiviral drug in the class of nucleotide analogs. It was developed by Gilead Sciences as a treatment for Ebola virus disease and Marburg virus infections

It has subsequently also been found to show antiviral activity against other single stranded RNA viruses such as corona virus (including MERS & SARS) Most importantly it has undergone success under many Clinical trails for the treatment of COVID-19 Disease


In late January 2020, Remdesivir was administered to the first US patient who was confirmed to be infected by SARS-CoV-2, in Snohomish County, Washington, for “compassionate use” after he progressed to pneumonia. While no broad conclusions were made based on the single treatment, the patient’s condition improved dramatically the next day The patient’s condition improve dramatically the next day

Gilead Sciences, Inc. is an American biotechnology company that researches, develops and commercializes drugs. The company focuses primarily on antiviral drugs used in the treatment of HIV, and influenza. Virus mainly

In 2013 to 2016 there was out break of Ebola in Western Africa during which gilead were asked to synthesis Remdesivir an Antiretroviral drug it was little effective towards ebola virus but worked to decrease of the outbreak

Remdesivir now can be used for COVID treatment it’s undergoing phase 3 of clinical trails to evaluate the safety and efficacy of remdesivir in adults diagnosed with COVID-19 (novel coronavirus). These randomized, open-label, multicenter studies will enroll approximately 1,000 patients at medical centers primarily across Asian countries, as well as other countries globally with high numbers of diagnosed cases, beginning in March

Mechanism of action of Corona virus

Remdesivirn (RDV) is broad spectrum of antiviral activities against RNA viruses, including SARS-CoV and Middle East respiratory syndrome (MERS-CoV)

RDV is a nucleotide analog inhibitor of RNA-dependent RNA polymerases (RdRps). Here, we co-expressed the MERS-CoV nonstructural proteins nsp5, nsp7, nsp8, and nsp12 (RdRp) in insect cells as a part a polyprotein to study the mechanism of inhibition of MERS-CoV RdRp by RDV

The triphosphate form of the inhibitor (RDV-TP) competes with its natural counterparts of viral ATP. The selectivity value for RDV-TP suggests that it is more efficiently incorporated than ATP and two other nucleotide analogues

Once incorporated the inhibitor caused RNA synthesis arrest hence mechanism of action is delayed RNA chain termination these results help to explain the high potency of RDV against RNA viruses in cell-based assays.


Niacin (VitaminB3) deficiency results in pellagra with deficiency manifestation that mainly involves skin, Gastrointestinal tract and Central Nervous system and thus includes dermatitis, diarrhoea, dementia and if not treated results in death.

Dermatitis mainly focuses on sun exposed part of skin involving area around the neck (Casal’s necklace), hand and feet (glove like appearance).

Since Niacin strictly speaking is not a Vitamin, pellagra like symptoms could also be seen due to Pyridoxal phosphate, Tryptophan, Riboflavin and Iron deficiency since these are required for the formation of Niacin from Tryptophan (an amino acid).

Thus pellagra like symptoms is seen in Hartnup’s disease where defective absorption of tryptophan from intestine takes place and Carcinoid syndrome where Tryptophan is diverted for the formation of serotonin.

Wernicke-Korsakoff’s syndrome

It is a neurological disorder where Wernicke’s encephalopathy and Korsakoff’s psychosis are acute and chronic phases respectively of the same disease.

Also known as cerebral beri beri is profoundly seen among chronic alcoholics. This is mainly because alcohol in the body reduces the thiamine (vitamin B1) absorption from the gastrointestinal tract and also conversion of thiamine to thiamine pyrophosphate (active form of thiamine).

It’s characterized by global confusion, opthalmoplegia, cerebral ataxia, memory loss, psychosis, retrograde and anterograde amnesia etc.

Ludwig’s angina

It is a skin infection which occurs in the floor of the mouth, underneath the tongue.It’s mainly a bacterial infection of streptococcus, staphylococcus etc. Primary site of infection is submandibular space (majority are odontogenic in etiology)
Poor dental hygiene, trauma/ laceration in the mouth, recent tooth extraction is the main cause for this condition.Symptoms include progressive swelling of soft tissue, elevation and posterior displacement of tongue, pain/ tenderness in the floor of the mouth, difficulty in swallowing, drooling, fever, redness on neck associated with pain, ear ache etc.The most life threatening complication is air obstruction with mortality of 8%.

Stone man syndrome

Also called Fibrodysplasia ossificans progressiva is a rare autosomal dominant disorder caused by the mutation of the gene ACVR1. It is the only known medical condition where one organ system changes into another. (A connective tissue disorder)Usual onset: Before the age of 10 with maximum life expectancy of 40 years. (Painful condition indeed with no treatment or cure)Mutations mainly affects body’s repair mechanism causing fibrous tissue including muscles, tendons and ligaments to be ossified either spontaneously or damaged as a result of trauma. Sometimes joints fuse themselves to form new bone. Bone growth generally progresses from the top of the body downwards just like ossification found in foetus.Signs: Malformed big toes, missing joints etc.
Since the disorder is rare, it is often misdiagnosed as cancer/ fibrosis.

Posterior canal benign paroxysmal positioning vertigo (posterior canal BPPV)

Main cause: canalithiasis/ cupulolithiasisTheoretically can affect each of three semicircular canal but most commonly posterior semicircular canal is affected.Common diagnostic manoeuvre: Dix-Hall pike manoeuvreSince posterior semicircular canal is the most gravity dependent part of vestibular labyrinth both in upright and supine position, once the debris enter into posterior canal, the cupular barrier in the shorter and more dependent end blocks the exit of debris.Patients complain of light-headedness, nausea, imbalance, reversal nystagmus and in severe cases, sensitivity to all direction of head movements also exists. In certain situation, though benign may become dangerous.Cause: idiopathicCommonly found age group: 50-70 yearsTerminologies used:
Canalithiasis: free floating particle within the semicircular canal.
Cupulolithiasis: particles adherent to cupula of semicircular canal.

Occulocutaneous Albinism

Occulocutaneous albinism

Overall estimation: 1 in 20000

Occulocutaneous albinism is a condition that mainly affects pigmentation of skin, hair, eyes. Affected individuals have very fair skin, light coloured hair with high risk of skin damage and are prone to even the most aggressive skin cancers like Melanoma.

Cause: Mutation in several genes including TYR, OCA2,TYRP1,SLC45A2 (gene responsible for producing melanin)
Occulocutaneous albinism is characterised as
Type I: whitish hair, paler skin, light coloured iris
Type II: creamy white coloured skin, light yellow or blon hair
Type III: usually affects dark skinned people. They posses reddish brown skin, red hair, brown iris.
Type IV: similar to type I

Marfan syndrome

Marfan syndrome is an inherited disorder, a rare genetic condition that mainly affects connective tissues and thus eventually heart, eyes, blood vessels, skeleton etc. They are usually tall and thin with disproportionately long arms, legs and fingers, protruding/ dipped breastbone, extreme nearsightedness, flat foot, heart murmurs etc.

It causes cardiovascular complications including aortic aneurysm, aortic dissection, valve malformations etc, eye complications including lens dislocation, retinal problems, early onset of cataracts etc, skeletal complications includes abnormal curves in the spines, arched palate and crowded teeth and complication of pregnancy also exist.
Treatment usually includes medications to keep a low blood pressure. Abraham Lincoln is the most famous American who had Marfan syndrome.

Eskimos diet and heart disease

Eskimos are believed to have a low incidence of coronary heart disease. They are actually indigenous people inhabiting northern Canada, Alaska, Greenland and eastern Siberia who traditionally live hunting seals and other arctic animals.

Bang and Dyerberg described Eskimo diet as consisting of large amount of seal and whale blubber (lipids containing unsaturated fatty acids).
The predominant unsaturated fatty acids in fish food consumed by Eskimos are 5, 8, 11, 14, eicsapentaenoic acid (EPA). These mainly inhibits formation of thromboxanes, a prostaglandin related compound which is responsible for platelet aggregation and thrombosis.

Anorexia nervosa

It is an eating disease characterised with low body mass index, distorted perception of weight and intense fear of gaining the weight. To prevent the weight gain they control calorie intake by vomiting after eating, misusing laxatives, inappropriate use of diuretics/ enemas. They also try to loose weight by excessive exercise.
It is a life threatening disorder with symptoms including high weight loss, abnormally low blood count, insomnia, absence of menstruation in females, constipation, abdominal pain, eroded teeth and calluses on the knuckles from induced vomiting.Some people with this condition may have obsessive compulsion personality traits that make it easier to stick to the strict diet plans. It is more common among teenagers.

Serene tears of the solace

Always, I float in the sea of emotions so i can be myself, not in realm of delusion

The fear i have buried inside me, is deeper then the lengths of Pascific sea, i was aghast that the world would find the secrets for its key.

Key to the deeper me, yes there is darkness, anger, jealousy, devil inside me,

I wonder even though i know i am broken inside, why that pain is unseen to me

I laugh to keep my darkness buried,I cry in the dark, but i know, it dont let the happiness and moments to embark.

Yes i am always anguish….Because Darkness always Replenishes in me its never gets extinguish

I donno how to get happy now….yes i sometimes have blissfull joy some how

But, now i know, The tears that flow, are the cure for all the agony and mourning we show

The Melancholy in life will perish you to death not to grace…..

Let your tears flow in peace, it can help you with your grief, I wish i knew this always,

So i titled the poetry

…………………..The serene tears of the solace……………………

Thank u

Please comment, share, like my work

Caution: There is one phase in life that everyone will go through so please dont judge me by my poetry.

Doctor, Diety to sick, god for both poor and rich.

The Decade of dedication and struggle, with lots of failure and full of troubles, with the torture of superiors, stress of exams or seniors, He is the idol of true endurance and perseverances

The seasons past beneath, and days fades away in leap, Books turns out to be wrinked and obsolete, the decade of medicine he studied in vain turns out even thats incomplete

He is grinded, He is sharpened, He is made to be elite, elite to save the life and bring the hope of light.

I wonder from where this selfless trait arouse? The suffering of Diseased, shedding of tears begging him for the life of your dears, Make him understand horizon of death, keeping beneath all his fears.

With his bread left behind, For his loved ones, he has no time, others can sleep in comfort and calm, he should be awake to save the life, checking vitals holding. wrist and palm

He is beaten, he is stoned, he is humiliated, he is killed, he fears no death, Still he stand strong, save the life of sick untill his last breath.

He is diety to sick, and god to poor and rich, He masks all his struggle and sorrow in the blush of empathy, to unmasks your suffering without any pity any sympathy

He treats the sufferers, he make pain and suffering disappears, He dedicates his life healing sick, both when days are normal or in pandemic making his life vulnerable at high risk.

Death has the rule of equality, both him and humans are treated with equity.

But, Death turns partial in his role, as he fights with death not for his life but others soul,

Death come to him with its face withering in guilt, waving away its role, Death in sorrow mourn’s his only soul.


Father is an unknown warrior to this world but greatest hero for his girl

For my father, my friend.

An understanding heart,

A soul of strength and support.

He was always my pillar when I knew I’d fall

Always my anchor, so strong and tall.

He taught me right from wrong.

I’ve grown up with your values. And I am very glad today

You built a strong foundation. No one can take away.

Without you Abbu jaan I wouldn’t be the person I am today.

He wasn’t a hero known by the world, but a hero he was to his little girl.

The Journey was more then just the Trip.

The sketching video you I’ll get it below.

In the place of life and death, where we talk with the bones and with flesh, My friend, in flip gave me the thought of trip, whispering in ear, holding my shoulder in his grip

Some were excited, some were doubted, some denied because of instances, some left behind by appaling circumstances, we were bunch of people started the journey, some were strangers well its was irony!!

The french Riviera of the east, we have reached our destiny before the dawn atleast.

Amusing were the beaches we explored, we were exited whole heartedly and that feeling cant be faded soo easily. All enjoyed in ocean like baby Pinnipeds, some came to pondy just to taste some squids.

As the sun was drowning, city was about to sleep, pub life pulled us to drink, dance and to be freak, some drank the wine, some danced out of order with lyrical line, some were busy taking the pics, we enjoyed the moment, with all the songs mix.

The Journey again started, the night in traveler was like animal we mounted, were we destined to “gift of the forests”, we were dancing all the night, then truth or dare i played it right.

Delighted by the games there were shooting,hitting and the horror house, Rafting the boat at the evening, quality moment with friends we spent it like blissful spring.

With the lake nearby, all were cycling, after many years of time, the feeling was soothing and the moment was mine, I closed my eyes, brain waves, gave me flash of childhood days , i say i cried, i prayed to god, bring my childhood back, oh!!! Lord…..oh!!! Lord

The journey was not the destiny, the strangers became the closest friends in that flip. the title is not mine but journey was just more then the trip.


Dedicated to my friends and our trip group

Journey#Me_ to_us#

Ammijan,The emotion melts the heart of man

She was the girl with the happiness and joy, with the showers of love and her friends whom she would annoy, She had a father who was her pride, with her mother she was whole heartedly suffice.

U are women to be, with lots of responsibility and life to see, says her mother, with her eyes full of tears.

Married she was, with the man she dint knew exists soofar. Should there be love for marraige? I ask u the question before

Adorable and wise was the man whom her hand was cynically given, unbelievablely she falls in love with his prasefull nature like heaven

Prasing wasnt enough, missing her mother she would cry, she was questioned for her childish tears by the people nearby.

Why would girl becomes women i question myself all the time, There woudnt be any suffering and pain, if that word was out of line.

God had his blessing, she was blessed with boy, now people called her a strong women, i dont why?

She was trilled, she was exited by the new life, she nurtured him, cherished him like her world was again suffice.

Cry of him, felt her like sword in heart, leaving all the chores she carries him apart.

She is omnipotent, she is omniscient, she is born scientist…oh!!! man, she is love of my life i call her Ammijan.

Dedicated to my mother


My love for you oh!! Dear is forever

In the midst of the darknezz
u are my star shining alwayzz,
losing you is my greatest fear
Well my love for u is firece

Everytime i think of u when i am cold
i am so lost as lost city of gold
the warm breathe of yours when u hug me
is so sharp,sharp enough to kill me

if god asks me a wish ever
i would want to be with you forever
Dare not to leave me
cuz nobody can love u like me

The love in shadow, is alive says the meadow.

The love in shadow, is alive says medow

They embrace me, they adore me more than there life, i was welcomed to their world with cake and knife

Their sleep in night faded away, They know my cry, I cant be quite when i crave, am not soo shy, They ill be awake untill i shut my eye.

I am there soul,am there part full of happiness,full of joy, Speaking, and walking learning to try

I can talk now and i can walk, i grew up till I trimmed my bearded hair like stalk

I grew up, i fell in love, with the girl who was like angel dove, They said its not love, they are hormones, i felt there words like sting of thrones

There words were sting of thrones it was true, but i got hurt and left them too😔

My love…! It faded away, it was my fate, i remembered they were saying, but it was late.

I had there memory, were we walking in meadow, I saw they have grown old in the darkness of shadow

The drowning of sun, the Chirping of birds, the wind flow, the love in the shadow is alive says the medow

There shadows will fade away, alive will be you, they really will grow old, See the sketch upside down as i told.

The life is full of happiness, until you plunder it away, There cant be more surprises, you know why did i say.I 

Is the corona virus infection curable?

The corona virus infection is treatable but not curable, it’s the myth which is running out in the Internet like the fire

At least seven companies have been warned by the Food and Drug Administration for fraudulent products like tea, oils etc to treat COVID-19.

There Is No Cure for COVID-19, No Matter What the Internet Says , Health line.

How is corona virus treated ?

Currently there no vaccine against the developing COVID-19 disease, and the antibiotics are not effective against the viral infection they only treat bacterial infection.

If your symptoms are more severe, supportive treatments may be given by your doctor or at a hospital. This type of treatment may involve:

    • Fluids to reduce the risk of dehydration
  • Medication to reduce a fever
  • Supplement oxygen in more severe cases
  • People who have a hard time breathing on their own may need repirator

Are there any drugs to treatment corona virus infection ?

There are many drugs which were before use to treat the outspread but for this modified virus they are not 100% effective

Do not take the drugs without doctor recommendation, they could be fatal.

The drugs given below are only for information based on WHO and CDC.

1. Remdesivir

Remdesivir Has Therapeutic Potential against SARS-CoV-2 Coronavirus, Scientists Say in sci news.

Remdesivir is an experimental broad-spectrum antiviral drug originally designed to target Ebola.

Researchers have found that remdesivir is highly effective at fighting the novel coronavirus in isolated cells.

2. Chloroquine

Can chloroquine cure coronavirus? Here’s what science says ,Digital trends.

Chloroquine is a drug that’s used to fight malaria and autoimmune diseases. It’s been in use for more than 70 years and is considered safe.

Researchers have discovered that this drug is effective at fighting the SARS-CoV-2 virus in studies done in test tubes.

3.Lopinavir and Ritonavir

Coronavirus: Health Ministry recommends anti-HIV drug combination Lopinavir-Ritonavir on case-to-case basis , India Today.

Lopinavir and ritonavir are sold under the name Kaletra and are designed to treat HIV.

In South Korea, a 54-year-old man was given a combination of these two drugs and had a significant reduction in his levels of the coronavirus.


‘Favilavir’: First Approved Drug to Possibly Treat Coronavirus, The science times.

China has approved the use of the antiviral drug favilavir to treat symptoms of COVID-19. The drug was initially developed to treat inflammation in the nose and throat.

The bottom line is

At this point in time, there’s no vaccines to protect you from the novel coronavirus, also known as SARS-CoV-2. There also are no special medications approved to treat the symptoms of COVID-19.

No FDA-approved drugs have demonstrated safety and efficacy in randomized controlled trials for patients with COVID-19. By CDC

The last moon before the dawn.

The Princess and the moon

The princess waiting for his love, who promised to be back when full moon glove.

The Intimacy of the princess to her love beholds to look at the darkest night ,seeing the moon reminds the promise of her knight

The prince went to the war with the promise looking the moon at night, Unconditional love of them made the moon to shine to its brightest light.

The prince perished in war remebering his love seeing the moon, At the time were the soul was about to leave him soon.

Prince never came back to her love, princess never let her love to vanish all above

The love to be eternal the princess never mourned his soul, she kept seeing the moon all night before the dawn until her body was cold

How does Corona Virus (SARC-CoV 2) causes the Pneumonia and multiple organ failure in patient with severe infection ?


Corona virus disease 2019 ( COVID-19) is a new name given to the disease caused by SARC-CoV-2 virus (Corona virus) this disease shows the same symptoms as that of common cold but the real fear arises when the infection goes to lower respiratory tract

Those affected may develop a fever, dry cough, fatigue, and shortness of breath. A sore throat, runny nose or sneezing is less common. While the majority of cases result in mild symptoms

When infection goes to Lower respiratory tract(LRT) it cause fatal disease like PNEUMONIA & MULTI ORAN FAILURE but the known conditions are only seen in people with compromised immunise system, old individual (age> 65) , people with long term medication, Diabetic are high prone to this fatal conditions when they are exposed to corona virus

Cause for pneumonia in corona virus

As the virus particle are mostly genetic and protienecous particle the spikes present on the virus coat have proteinecous messengers which have similarities with SARC viral coat they both have same receptors which are present specifically on Angiotensin converting enzymes 2 receptors (ACE 2) which are present on the lungs.

The viral particle takes the machinery of the host cells due to there activity the immune response initiate that will act in enormous way such that the fluid build up in the alveoli.

Both The lungs will get filled with fluid and waste exudates from the blood due to vasodilation for immune response this causes bacteria a culture and majorly it causes pneumonia

Why does multiple organ failure comes in the picture

When both the lung are filled with fluid the respiration is compromised causing hypoxia (decreased oxygen supply to tissue) which causes decreased O2 saturation level

At this time infection starts spreading all over the body. The bacterial cell flowing through blood activates the macrophages for scavenging the lots of bacteria. Due to this the small clots get formed in the body which decreases the blood Supply to major organs, and also causes the severe septic shock leading to shut down of body organ system turns out to be death of individual

1. The 3 cases explained well to understand how virus works

2. How virus jumps from Animals to Humans

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The corona virus spread in India and the world.

There is now a total of 1,09,577 reported cases of COVID-19 globally, and 3,809 deaths.

In the past 24 hours, China reported 129 cases, since the 3rd of March

Outside China, 1848 cases were reported in 48 countries. 80% of those cases are from just three countries: the Republic of Korea, the Islamic Republic of Iran and Italy.

12 new countries have reported their first cases, and there are now 21 countries with one case. 

122 countries have not reported any cases.

Evidence from China is that only 1% of reported cases do not have symptoms, and most of those cases develop symptoms within 2 days

Globally, about 3.4% of reported COVID-19 cases have died. By comparison, seasonal flu generally kills far fewer than 1% of those infected

WHO has shipped nearly half a million sets of personal protective equipment to 27 countries, but supplies are rapidly depleting.

WHO estimates that each month, 89 million medical masks will be required for the COVID-19 response; 76 million examination gloves, and 1.6 million goggles.


1. World Health Organisation

Coronavirus advisory information

Coronavirus condition overview

2. Why is CNN calling Corona virus outbreak a pandemic

Epidemiologists and public health experts argue the world is already experiencing a pandemic because of the novel coronavirus.

There are now over 100,000 cases and over 3,000 deaths attributed to this new virus. In one day last week, the number of new cases outside of China, where the virus originated, was nearly 9 times higher than the number of new cases in China.


1. CORONA VIRUS OUTBREAKS INDIA. Total cases in India rise to 45 after Karnataka records first +ve confirmed COVID-19

A software engineer who returned from the US recently has tested positive for the novel coronavirus, becoming the first COVID-19 patient in Karnataka, state minister K Sudhakar said.

The man had come from Austin in the US along with his wife and daughter on March 1 After going to a private hospital on noticing symptoms, he had voluntarily approached the Rajiv Gandhi Institute of Chest Diseases on March 8.

2. Punjab confirm first positive case of corona virus, patient had travelled Italy

The patient is a resident of Hoshiarpur, he said, adding he was tracked at the Amritsar airport and got admitted to a government hospital in Amritsar.

After he was found coronavirus-positive last week after a preliminary investigation, his samples were sent to National Institute of Virology, Pune, which confirmed on Monday that the man is suffering from, coronavirus afflictions.

What is corona virus ?

Coronaviruses were first discovered in the 1960s. The earliest ones discovered were infectious bronchitis virus in chickens and two viruses from the nasal cavities of human patients with the common cold that were subsequently named human coronavirus 229E and human coronavirus OC43.

Corona virus (COVID 19) are enveloped viruses with a positive-sense single-stranded RNA-genome and a nucleocapsid of helical symmetry. The genome size of coronaviruses, ranges from approximately 27 to 34 kilobases, the largest among known RNA viruses.

The name refers to the characteristic appearance.. of virions (the infective form of the virus) by electron microscopymeaning crown now we reach the era where the world is full of greed to achieve to the greatness out of which the nature selects vast destruction of human in all way it can now it is in the face the the death to begun CORONA VIRUS (COVID-19)